LymphedemaV1, Main, Exploration, bibRecord, 001E44

Electroacupuncture Versus Gabapentin for Hot Flashes Among Breast Cancer Survivors: A Randomized Placebo-Controlled Trial

Identifieur interne : 001E44 ( Main/Exploration ); précédent : 001E43; suivant : 001E45

Electroacupuncture Versus Gabapentin for Hot Flashes Among Breast Cancer Survivors: A Randomized Placebo-Controlled Trial

Auteurs : Jun J. Mao ; Marjorie A. Bowman ; Sharon X. Xie ; Deborah Bruner ; Angela Demichele ; John T. Farrar

Source :

Journal of Clinical Oncology [ 0732-183X ] ; 2015.

RBID : PMC:4622101

Abstract

Purpose

Hot flashes are a common and debilitating symptom among survivors of breast cancer. This study aimed at evaluating the effects of electroacupuncture (EA) versus gabapentin (GP) for hot flashes among survivors of breast cancer, with a specific focus on the placebo and nocebo effects.

Patients and Methods

We conducted a randomized controlled trial involving 120 survivors of breast cancer experiencing bothersome hot flashes twice per day or greater. Participants were randomly assigned to receive 8 weeks of EA or GP once per day with validated placebo controls (sham acupuncture [SA] or placebo pills [PPs]). The primary end point was change in the hot flash composite score (HFCS) between SA and PP at week 8, with secondary end points including group comparisons and additional evaluation at week 24 for durability of treatment effects.

Results

By week 8, SA produced significantly greater reduction in HFCS than did PP (−2.39; 95% CI, −4.60 to −0.17). Among all treatment groups, the mean reduction in HFCS was greatest in the EA group, followed by SA, GP, and PP (−7.4 v −5.9 v −5.2 v −3.4; P = < .001). The pill groups had more treatment-related adverse events than did the acupuncture groups: GP (39.3%), PP (20.0%), EA (16.7%), and SA (3.1%), with P = .005. By week 24, HFCS reduction was greatest in the EA group, followed by SA, PP, and GP (−8.5 v −6.1 v −4.6 v −2.8; P = .002).

Conclusion

Acupuncture produced larger placebo and smaller nocebo effects than did pills for the treatment of hot flashes. EA may be more effective than GP, with fewer adverse effects for managing hot flashes among breast cancer survivors; however, these preliminary findings need to be confirmed in larger randomized controlled trials with long-term follow-up.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622101

DOI: 10.1200/JCO.2015.60.9412
PubMed: 26304905
PubMed Central: 4622101

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Electroacupuncture Versus Gabapentin for Hot Flashes Among Breast Cancer Survivors: A Randomized Placebo-Controlled Trial</title>
<author><name sortKey="Mao, Jun J" sort="Mao, Jun J" uniqKey="Mao J" first="Jun J." last="Mao">Jun J. Mao</name>
<affiliation><nlm:aff id="aff1">Jun J. Mao, Sharon X. Xie, Angela DeMichele, and John T. Farrar, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Marjorie A. Bowman, Wright State University Boonshoft School of Medicine, Dayton, OH; and Deborah Bruner, Emory University Nell Hodgson Woodruff School of Nursing, Atlanta, GA.</nlm:aff>
<wicri:noCountry code="subfield">GA.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Bowman, Marjorie A" sort="Bowman, Marjorie A" uniqKey="Bowman M" first="Marjorie A." last="Bowman">Marjorie A. Bowman</name>
<affiliation><nlm:aff id="aff1">Jun J. Mao, Sharon X. Xie, Angela DeMichele, and John T. Farrar, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Marjorie A. Bowman, Wright State University Boonshoft School of Medicine, Dayton, OH; and Deborah Bruner, Emory University Nell Hodgson Woodruff School of Nursing, Atlanta, GA.</nlm:aff>
<wicri:noCountry code="subfield">GA.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Xie, Sharon X" sort="Xie, Sharon X" uniqKey="Xie S" first="Sharon X." last="Xie">Sharon X. Xie</name>
<affiliation><nlm:aff id="aff1">Jun J. Mao, Sharon X. Xie, Angela DeMichele, and John T. Farrar, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Marjorie A. Bowman, Wright State University Boonshoft School of Medicine, Dayton, OH; and Deborah Bruner, Emory University Nell Hodgson Woodruff School of Nursing, Atlanta, GA.</nlm:aff>
<wicri:noCountry code="subfield">GA.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Bruner, Deborah" sort="Bruner, Deborah" uniqKey="Bruner D" first="Deborah" last="Bruner">Deborah Bruner</name>
<affiliation><nlm:aff id="aff1">Jun J. Mao, Sharon X. Xie, Angela DeMichele, and John T. Farrar, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Marjorie A. Bowman, Wright State University Boonshoft School of Medicine, Dayton, OH; and Deborah Bruner, Emory University Nell Hodgson Woodruff School of Nursing, Atlanta, GA.</nlm:aff>
<wicri:noCountry code="subfield">GA.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Demichele, Angela" sort="Demichele, Angela" uniqKey="Demichele A" first="Angela" last="Demichele">Angela Demichele</name>
<affiliation><nlm:aff id="aff1">Jun J. Mao, Sharon X. Xie, Angela DeMichele, and John T. Farrar, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Marjorie A. Bowman, Wright State University Boonshoft School of Medicine, Dayton, OH; and Deborah Bruner, Emory University Nell Hodgson Woodruff School of Nursing, Atlanta, GA.</nlm:aff>
<wicri:noCountry code="subfield">GA.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Farrar, John T" sort="Farrar, John T" uniqKey="Farrar J" first="John T." last="Farrar">John T. Farrar</name>
<affiliation><nlm:aff id="aff1">Jun J. Mao, Sharon X. Xie, Angela DeMichele, and John T. Farrar, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Marjorie A. Bowman, Wright State University Boonshoft School of Medicine, Dayton, OH; and Deborah Bruner, Emory University Nell Hodgson Woodruff School of Nursing, Atlanta, GA.</nlm:aff>
<wicri:noCountry code="subfield">GA.</wicri:noCountry>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">26304905</idno>
<idno type="pmc">4622101</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622101</idno>
<idno type="RBID">PMC:4622101</idno>
<idno type="doi">10.1200/JCO.2015.60.9412</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">000290</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000290</idno>
<idno type="wicri:Area/Pmc/Curation">000290</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000290</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001301</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001301</idno>
<idno type="wicri:Area/Ncbi/Merge">007788</idno>
<idno type="wicri:Area/Ncbi/Curation">007788</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">007788</idno>
<idno type="wicri:doubleKey">0732-183X:2015:Mao J:electroacupuncture:versus:gabapentin</idno>
<idno type="wicri:Area/Main/Merge">001E47</idno>
<idno type="wicri:Area/Main/Curation">001E44</idno>
<idno type="wicri:Area/Main/Exploration">001E44</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Electroacupuncture Versus Gabapentin for Hot Flashes Among Breast Cancer Survivors: A Randomized Placebo-Controlled Trial</title>
<author><name sortKey="Mao, Jun J" sort="Mao, Jun J" uniqKey="Mao J" first="Jun J." last="Mao">Jun J. Mao</name>
<affiliation><nlm:aff id="aff1">Jun J. Mao, Sharon X. Xie, Angela DeMichele, and John T. Farrar, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Marjorie A. Bowman, Wright State University Boonshoft School of Medicine, Dayton, OH; and Deborah Bruner, Emory University Nell Hodgson Woodruff School of Nursing, Atlanta, GA.</nlm:aff>
<wicri:noCountry code="subfield">GA.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Bowman, Marjorie A" sort="Bowman, Marjorie A" uniqKey="Bowman M" first="Marjorie A." last="Bowman">Marjorie A. Bowman</name>
<affiliation><nlm:aff id="aff1">Jun J. Mao, Sharon X. Xie, Angela DeMichele, and John T. Farrar, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Marjorie A. Bowman, Wright State University Boonshoft School of Medicine, Dayton, OH; and Deborah Bruner, Emory University Nell Hodgson Woodruff School of Nursing, Atlanta, GA.</nlm:aff>
<wicri:noCountry code="subfield">GA.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Xie, Sharon X" sort="Xie, Sharon X" uniqKey="Xie S" first="Sharon X." last="Xie">Sharon X. Xie</name>
<affiliation><nlm:aff id="aff1">Jun J. Mao, Sharon X. Xie, Angela DeMichele, and John T. Farrar, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Marjorie A. Bowman, Wright State University Boonshoft School of Medicine, Dayton, OH; and Deborah Bruner, Emory University Nell Hodgson Woodruff School of Nursing, Atlanta, GA.</nlm:aff>
<wicri:noCountry code="subfield">GA.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Bruner, Deborah" sort="Bruner, Deborah" uniqKey="Bruner D" first="Deborah" last="Bruner">Deborah Bruner</name>
<affiliation><nlm:aff id="aff1">Jun J. Mao, Sharon X. Xie, Angela DeMichele, and John T. Farrar, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Marjorie A. Bowman, Wright State University Boonshoft School of Medicine, Dayton, OH; and Deborah Bruner, Emory University Nell Hodgson Woodruff School of Nursing, Atlanta, GA.</nlm:aff>
<wicri:noCountry code="subfield">GA.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Demichele, Angela" sort="Demichele, Angela" uniqKey="Demichele A" first="Angela" last="Demichele">Angela Demichele</name>
<affiliation><nlm:aff id="aff1">Jun J. Mao, Sharon X. Xie, Angela DeMichele, and John T. Farrar, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Marjorie A. Bowman, Wright State University Boonshoft School of Medicine, Dayton, OH; and Deborah Bruner, Emory University Nell Hodgson Woodruff School of Nursing, Atlanta, GA.</nlm:aff>
<wicri:noCountry code="subfield">GA.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Farrar, John T" sort="Farrar, John T" uniqKey="Farrar J" first="John T." last="Farrar">John T. Farrar</name>
<affiliation><nlm:aff id="aff1">Jun J. Mao, Sharon X. Xie, Angela DeMichele, and John T. Farrar, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Marjorie A. Bowman, Wright State University Boonshoft School of Medicine, Dayton, OH; and Deborah Bruner, Emory University Nell Hodgson Woodruff School of Nursing, Atlanta, GA.</nlm:aff>
<wicri:noCountry code="subfield">GA.</wicri:noCountry>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of Clinical Oncology</title>
<idno type="ISSN">0732-183X</idno>
<idno type="eISSN">1527-7755</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Purpose</title>
<p>Hot flashes are a common and debilitating symptom among survivors of breast cancer. This study aimed at evaluating the effects of electroacupuncture (EA) versus gabapentin (GP) for hot flashes among survivors of breast cancer, with a specific focus on the placebo and nocebo effects.</p>
</sec>
<sec><title>Patients and Methods</title>
<p>We conducted a randomized controlled trial involving 120 survivors of breast cancer experiencing bothersome hot flashes twice per day or greater. Participants were randomly assigned to receive 8 weeks of EA or GP once per day with validated placebo controls (sham acupuncture [SA] or placebo pills [PPs]). The primary end point was change in the hot flash composite score (HFCS) between SA and PP at week 8, with secondary end points including group comparisons and additional evaluation at week 24 for durability of treatment effects.</p>
</sec>
<sec><title>Results</title>
<p>By week 8, SA produced significantly greater reduction in HFCS than did PP (−2.39; 95% CI, −4.60 to −0.17). Among all treatment groups, the mean reduction in HFCS was greatest in the EA group, followed by SA, GP, and PP (−7.4 <italic>v</italic>
 −5.9 <italic>v</italic>
 −5.2 <italic>v</italic>
 −3.4; <italic>P</italic>
 = < .001). The pill groups had more treatment-related adverse events than did the acupuncture groups: GP (39.3%), PP (20.0%), EA (16.7%), and SA (3.1%), with <italic>P</italic>
 = .005. By week 24, HFCS reduction was greatest in the EA group, followed by SA, PP, and GP (−8.5 <italic>v</italic>
 −6.1 <italic>v</italic>
 −4.6 <italic>v</italic>
 −2.8; <italic>P</italic>
 = .002).</p>
</sec>
<sec><title>Conclusion</title>
<p>Acupuncture produced larger placebo and smaller nocebo effects than did pills for the treatment of hot flashes. EA may be more effective than GP, with fewer adverse effects for managing hot flashes among breast cancer survivors; however, these preliminary findings need to be confirmed in larger randomized controlled trials with long-term follow-up.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Bowman, Marjorie A" sort="Bowman, Marjorie A" uniqKey="Bowman M" first="Marjorie A." last="Bowman">Marjorie A. Bowman</name>
<name sortKey="Bruner, Deborah" sort="Bruner, Deborah" uniqKey="Bruner D" first="Deborah" last="Bruner">Deborah Bruner</name>
<name sortKey="Demichele, Angela" sort="Demichele, Angela" uniqKey="Demichele A" first="Angela" last="Demichele">Angela Demichele</name>
<name sortKey="Farrar, John T" sort="Farrar, John T" uniqKey="Farrar J" first="John T." last="Farrar">John T. Farrar</name>
<name sortKey="Mao, Jun J" sort="Mao, Jun J" uniqKey="Mao J" first="Jun J." last="Mao">Jun J. Mao</name>
<name sortKey="Xie, Sharon X" sort="Xie, Sharon X" uniqKey="Xie S" first="Sharon X." last="Xie">Sharon X. Xie</name>
</noCountry>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001E44 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001E44 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    LymphedemaV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:4622101
   |texte=   Electroacupuncture Versus Gabapentin for Hot Flashes Among Breast Cancer Survivors: A Randomized Placebo-Controlled Trial
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:26304905" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a LymphedemaV1

This area was generated with Dilib version V0.6.31.
Data generation: Sat Nov 4 17:40:35 2017. Site generation: Tue Feb 13 16:42:16 2024

Serveur d'exploration sur le lymphœdème

Electroacupuncture Versus Gabapentin for Hot Flashes Among Breast Cancer Survivors: A Randomized Placebo-Controlled Trial

Electroacupuncture Versus Gabapentin for Hot Flashes Among Breast Cancer Survivors: A Randomized Placebo-Controlled Trial

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur le lymphœdème
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.